MSI Testing: Role in Colorectal Cancer Diagnosis & Treatment

MSI testing, or microsatellite instability testing, is a diagnostic pathology test used to identify abnormalities in the DNA of cancer cells. Microsatellites are repeated sequences of DNA that are prone to errors during replication.

When these errors accumulate, it leads to microsatellite instability (MSI), which is a hallmark of certain types of cancer, particularly colorectal cancer.

MSI testing helps to determine whether a patient's tumor exhibits microsatellite instability. This information is crucial in cancer diagnosis and treatment planning.

For example, MSI testing can identify patients with Lynch syndrome, a hereditary condition that predisposes individuals to certain types of cancer, including colorectal cancer.

The test involves analyzing specific DNA markers in the tumor tissue to assess microsatellite stability. A positive result indicates high levels of microsatellite instability, while a negative result suggests that the microsatellites are stable.

Apart from colorectal cancer, MSI testing is also used in other cancer types such as endometrial, gastric, and ovarian cancers. It plays a vital role in personalized medicine by guiding treatment decisions based on the genetic makeup of the tumor.

What is the Purpose of Performing a MSI Testing Test?

The primary purpose of MSI testing is to identify microsatellite instability in cancer cells.

• MSI testing helps in diagnosing Lynch syndrome, a hereditary condition associated with an increased risk of developing colorectal and other cancers.
• MSI status can predict a patient's response to immunotherapy, a type of cancer treatment that boosts the body's immune system to fight cancer cells.
• MSI testing can guide treatment decisions by identifying patients who are likely to benefit from certain therapies, such as immune checkpoint inhibitors.

By understanding the MSI status of a tumor, healthcare providers can tailor treatment plans to maximize effectiveness and minimize side effects for patients.

This personalized approach to cancer care is transforming the field of oncology and improving outcomes for many individuals.

What are the Costs of MSI Testing Tests in India?

The cost of MSI testing in India can vary depending on several factors, including the laboratory, location, and type of test performed. On average, the price range for MSI testing in India is between INR 10,000 to INR 20,000.

Factors that can influence the cost of MSI testing include the complexity of the test, the technology used, and any additional services offered by the laboratory.

It is essential for patients to inquire about the total cost of the test upfront and check if it is covered by insurance or any healthcare benefits.

Comparing prices from different laboratories and healthcare providers can help patients find a cost-effective option without compromising the quality and accuracy of the test results.

It is essential to consider both the cost and the quality of service when choosing where to undergo MSI testing in India.

What is the Normal Range and All Values of MSI Testing?

The normal range of MSI testing refers to the level of microsatellite stability in tumor cells. A normal result indicates that the microsatellites are stable, while an abnormal result suggests microsatellite instability.

Here is a breakdown of the values of MSI testing: