HE4 Test: Ovarian Cancer Detection & Prognosis Prediction

The HE4 test, also known as Human Epididymis Protein 4, is a diagnostic blood test used to detect the presence of HE4 protein in the blood.

HE4 is a protein that is produced by some ovarian cancer cells and is often elevated in women with ovarian cancer.

This test is commonly used in conjunction with other tests, such as CA-125, to help diagnose ovarian cancer. HE4 testing can also be used to monitor the progression of the disease and to determine the effectiveness of treatment.

In addition to ovarian cancer, HE4 testing has also shown promise as a biomarker for endometrial and lung cancers.

By measuring the levels of HE4 in the blood, healthcare providers can gain valuable insights into a patient’s cancer status and prognosis.

• Examples of related concepts include:
• HE4 biomarker
• Ovarian cancer test
• Endometrial cancer marker
• HE4 screening
• Women's cancer biomarkers

What is the Purpose of Performing a HE4 Test?

The primary purpose of performing a HE4 test is to aid in the detection and monitoring of ovarian cancer.

By measuring the levels of HE4 in the blood, healthcare providers can assess the risk of ovarian cancer in patients with suspicious symptoms or abnormal imaging results.

Additionally, HE4 testing can help in predicting the prognosis of ovarian cancer. High levels of HE4 have been associated with more aggressive forms of the disease and poorer outcomes.

This information can guide treatment decisions and help healthcare providers tailor the most effective therapies for their patients.

When used in combination with CA-125, another biomarker for ovarian cancer, HE4 testing can provide a more comprehensive assessment of a patient’s cancer status. The two tests together can offer a more accurate diagnosis and monitoring of ovarian cancer.

What are the Costs of HE4 Test Tests in India?

The costs of HE4 testing in India can vary depending on the laboratory or healthcare facility where the test is conducted. In general, the price range for a HE4 test in India can fall between INR 2000 to INR 5000.

Factors that can influence the cost of HE4 testing in India include the location of the laboratory, the method used for testing, and any additional services or consultations that may be included in the test package.

It is advisable to inquire about the specific cost of the test at the chosen facility before undergoing the test.

What is the Normal Range and All Values of HE4 Test?

The normal range for HE4 levels in the blood can vary depending on the laboratory and the specific assay used for testing. In general, the normal range for HE4 is considered to be less than 70 pmol/L.

Below is a table showing the ranges and their meanings:

HE4 Level (pmol/L)	Interpretation
Less than 70	Normal
70-140	Borderline elevated levels, further testing may be needed
Greater than 140	Elevated levels, indicative of potential ovarian cancer

What Do High HE4 Test Levels Indicate?

High levels of HE4 in the blood can indicate a higher risk of ovarian cancer. Elevated HE4 levels are often seen in women with ovarian cancer, particularly in advanced stages of the disease.

Other conditions that can cause high HE4 levels include endometrial cancer, lung cancer, and other gynecologic malignancies. In some cases, benign conditions such as endometriosis or ovarian cysts can also lead to elevated HE4 levels.

• Examples of causes and risks associated with high HE4 levels include:
• Ovarian cancer
• Endometrial cancer
• Lung cancer
• Gynecologic malignancies

What Do Low HE4 Test Levels Indicate?

Low levels of HE4 in the blood are considered normal and do not typically indicate any underlying health conditions. However, in some cases, low HE4 levels may be seen in patients with early-stage ovarian cancer or other types of cancer.

It is essential to interpret HE4 test results in conjunction with other diagnostic tests and clinical evaluations to determine the significance of low HE4 levels.

Healthcare providers will consider the overall clinical picture to make an accurate diagnosis and treatment plan.

In summary, the HE4 test is a valuable tool in the diagnosis and monitoring of ovarian cancer, as well as other gynecologic and non-gynecologic malignancies.

By measuring the levels of HE4 in the blood, healthcare providers can gain valuable insights into a patient’s cancer status and prognosis, leading to more personalized and effective treatment strategies.