EGFR Mutation Testing: Diagnostic Pathology Test for Lung Cancer

Epidermal Growth Factor Receptor (EGFR) is a protein found on the surface of cells that plays a crucial role in cell growth and division.

Mutations in the EGFR gene can lead to uncontrolled cell growth, which is a common characteristic of cancer.

In the context of lung cancer, EGFR mutation testing is essential to identify specific mutations in the EGFR gene that can drive the growth of cancer cells.

Examples of EGFR mutations include exon 19 deletions and L858R mutations, which are common in non-small cell lung cancer (NSCLC).

These mutations can be targeted with specific therapies that block the activity of the mutated EGFR protein, leading to better treatment outcomes for patients.

Understanding EGFR mutations in lung cancer is crucial for personalized treatment decisions. By identifying specific mutations, doctors can use targeted therapies that specifically inhibit the mutated EGFR protein, leading to more effective and less toxic treatment options for patients.

What is the Purpose of Performing an Epidermal Growth Factor Receptor Mutation Test?

The primary purpose of performing an EGFR mutation test is to identify specific mutations in the EGFR gene that can drive the growth of cancer cells.

This information is essential for guiding treatment decisions and selecting the most effective therapies for patients with lung cancer.

EGFR mutation testing is particularly important in non-small cell lung cancer (NSCLC), where specific mutations can be targeted with FDA-approved therapies such as tyrosine kinase inhibitors (TKIs).

By identifying these mutations, doctors can tailor treatment plans to individual patients, leading to better outcomes and improved quality of life.

In addition to guiding treatment decisions, EGFR mutation testing can also help predict response to therapy and monitor disease progression.

By monitoring changes in EGFR mutations over time, doctors can adjust treatment strategies accordingly, ensuring the best possible outcomes for patients with lung cancer.

What are the Costs of Epidermal Growth Factor Receptor Mutation Tests in India?

The cost of EGFR mutation testing in India can vary depending on the specific test used, the laboratory performing the test, and any additional services included in the testing process.

On average, the cost of an EGFR mutation test in India can range from INR 10,000 to INR 20,000.

Factors that can influence the cost of EGFR mutation testing in India include the type of test used (e.g., PCR-based testing, next-generation sequencing), the complexity of the test, and whether additional genetic testing is required.

It is important for patients to discuss the cost of testing with their healthcare provider and insurance company to understand potential out-of-pocket expenses.

When comparing the cost of EGFR mutation testing in India to other countries, it is important to consider the quality of testing, expertise of the laboratory, and turnaround time for results.

While cost is an important factor, ensuring accurate and timely testing is crucial for guiding treatment decisions in patients with lung cancer.

What is the Normal Range and All Values of Epidermal Growth Factor Receptor Mutation?

The normal range for EGFR mutation testing depends on the specific mutation being tested for and the laboratory performing the test.

Common EGFR mutations in lung cancer include exon 19 deletions and L858R mutations, which are associated with targeted therapies such as tyrosine kinase inhibitors (TKIs).

The table below shows the range of EGFR mutations and their meanings: